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We're moving beyond basic maintenance and into strategic investment - targeting the very biology of ageing itself

doi: 10.1080/03602532.2016.1197239, 76

Real-world outcomes show that patients on insulin plus semaglutide lose an average of 515% of body weight over 612 months, depending on starting dose and adherence

Waiting 45 weeks gets you to steady-state levels before increasing, which makes it easier to tell whether side effects come from the dose escalation or just normal fluctuation

Other adherence studies suggest oral semaglutide can perform similarly to established oral therapies and, in some groups, may show better persistence than injectable semaglutide over 12 months (source)