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severe persistent abdominal pain, sometimes radiating to the back, with or without vomiting Gallbladder disease Acute kidney injury (usually secondary to dehydration from gastrointestinal symptoms) Hypersensitivity reactions Worsening of diabetic retinopathy in patients with pre-existing retinopathy For weight management patients (Zepbound): Monitor for depression or suicidal thoughts Establishing a consistent, sustainable injection schedule is essential for treatment adherence and optimal therapeutic outcomes with tirzepatide

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These receptors are highly concentrated in adipose tissue (particularly visceral fat and brown fat) but have limited expression in most other tissues in adult humans

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