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It works best close to the injured tissue

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Long-lasting symptoms may represent a continuum with those of the acute phase, thus long-COVID-19 has a beginning but not a definite end (Seele et al

Collectively, it may be hypothesized that obesity induces feedback inhibition of pituitary GH secretion by increasing non-fasting serum FFA levels and the associated insulin resistance that causes compensatory intra-portal hyperinsulinemia and IGFBP-1 suppression, with the net result being low GH and normal IGF-I levels

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