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Loren Pickart in 1973, GHK-Cu was discovered when Pickart observed that albumin from young donors (age 20-25) could stimulate aged liver tissue to synthesize proteins at a youthful rate, and the active factor was traced to this small copper peptide

Like other copper-binding tripeptides, its biological effects are proposed to occur through both the peptide backbone and the copper ion it coordinates with the copper contributing to enzymatic cofactor activity and oxidative stress modulation

[29] Thus, the controversies regarding the effectiveness of oral glutathione continues to pose a challenge to its prescribers [Box 4]

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