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Although the role of QCN as an anti-inflammatory agent was evident, it failed to significantly reduce cytokine levels compared with the DFU group

In pathologic conditions, the loss of HS disrupts the charge selectivity of the glomerular filtration barrier, which increases the filtration of proteins and leads to proteinuria (97)

We introduce these definitions early because the same phenolic cargo can behave as an antioxidant, a pro-oxidant, or a signaling modulator depending on dose, local metal availability, pH, compartmentalization, and the surrounding biomolecular milieu ( Mesoporous silica nanoparticles (MSNs) provide a modular platform to partially decouple intrinsic phenolic chemistry from in vivo performance

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