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Increasing Insulin Release The GLP-1 pill stimulates your pancreas to release more insulin, but only when your blood sugar is elevated

All regressions and plots were generated using GraphPad Prism

They have been characterized previously and express the GLP-1R at 1 pmol/mg total cellular protein with a K d for GLP-1 736 amide of 1 nM [7]

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This has been attributed in part to reduced expression of their receptors as a consequence of glucotoxicity [2], a possibility supported by the observation that normalisation of blood glucose levels in patients with type 2 diabetes restores the efficacy of GLP-1 and GIP [3]