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The careful analysis of the outcomes of the clinical trials evaluating GLS inhibition in combination with immune checkpoint inhibitors in patients with solid tumors, including non-small-cell lung cancer (NSCLC), melanoma, and clear cell renal cell carcinoma (ccRCC) (NCT03894540, NCT02771626, and NCT04265534 that were all terminated), would be critical for assessment the potential clinical benefit from combining Gln metabolism blockage and immune therapies

Transcriptional impact of dietary methionine restriction on systemic inflammation: relevance to biomarkers of metabolic disease during aging

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