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Prufer, K., Veenstra, T

The formulation also exhibited high drug loading efficiency (74.65%), stable physicochemical properties across gastrointestinal pH conditions for at least 14 days and excellent in vitro biocompatibility over a wide concentration range (0120 M)

The role of R-2-HG as an oncometabolite has been implicated in epigenetic modifications through the inhibition of -KG-dependent dioxygenases and demethylases, which has been assumed to be a driver of tumorigenesis 117,118