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(2020) revealed that gambogenic acid (GNA) could suppress the invasive and migratory capacities as well as the EMT process in melanoma cells, which showed signature ferroptosis morphological changes

[DOI] [PMC free article] [PubMed] [Google Scholar] Avni T, Lador A, Lev S, Leibovici L, Paul M, Grossman A (2015) Vasopressors for the treatment of septic shock: systematic review and meta-analysis

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However, despite low plasma concentrations, pharmacokinetic studies show that berberine has a high tissue distribution rate, accumulating effectively in the liver, kidneys, muscle, and heart where it exerts its metabolic effects

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