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It is currently the phase II drug associated with the greatest weight reduction, achieving a 24% decrease (28.5% in women) after 48 weeks with a weekly dose of 12 mg55 (Table 1), and providing significant benefits in the control of cardiovascular risk factors and the reduction of MASLD56 (Fig

Individuals classified as responders often exhibit higher microbial diversity and greater relative abundance of SCFA-producing and anti-inflammatory taxa, including Roseburia , Faecalibacterium , and Butyricicoccus

5 Gut microbiota as a regulator of metabolism and -cell function Contemporary studies confirm the close interconnection between the gut and the pancreatic islet apparatus, commonly referred to as the gutislet axis (Marroncini et al., 2024) (Figure 1C)

doi: 10.4161/ISL.3.4.15728 50 GootjesCZwagingaJJRoepBONikolicT

These trials are currently ongoing and aim to address the issue of drug resistance while minimizing adverse reactions in clinical settings