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As an example, in experimental conditions with animal models (GLP-1R-null), TZP reduced appetite and food intake, liver glycogenolysis and gluconeogenesis, improved insulin sensibility (assessed by euglycemic clamp) and glucose disposal in white and brown adipose tissue, skeletal muscle, with body weight-dependent and independent effects (73)

This off-label trend is fueled by TikTok testimonials and celebrity endorsements, often ignoring the clinical guidelines

Caron, J., Domenger, D., Dhulster, P., Ravallec, R