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Rapid weight loss can signal energy deficiency to the hypothalamus, potentially suppressing gonadotropin-releasing hormone (GnRH) secretion

In PD, along with -synuclein accumulation, there is associated inflammation, synaptic dysfunction, dopaminergic neuronal loss, and some data to suggest insulin resistance

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Gene structure and expression regulation Human APOA1/C3/A4/A5 gene clusters are located on chromosome 11q23, where APOC3 gene is approximately 35 kbp upstream from the APOA5 gene locus [9]

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