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Future cohort studies should consider the risk for reverse causation introduced by pancreatic cancer-related diabetes where the diabetes is paraneoplastic in response to the pancreatic tumor 46

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This is further supported by the finding that SOD activity is increased during active disease and returns to normal in remission (157).Additionally, the presence of oxidative damage and the inhibition of catalase, an antioxidant enzyme, in CD patients immune cells further underscores oxidative stresss role in the disease (158)

In addition, SEM analysis was conducted on post-melted samples

Changes relative to baseline lean mass were similar between the groups, and meta-regression analysis indicated that reductions in total body weight were significantly associated with fat mass loss but not with lean mass