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The Q-Exactive Plus Mass Spectrometer (Thermo Fisher Scientific) was equipped with electrospray ionization (ESI) operated in the positive mode: ESI spray voltage +3.8 kV, sheath gas (N 2 ) 20 a.u., auxiliary gas (N 2 ) 5 a.u., capillary temperature 320 C, and mass resolution 70,000 at m/z 400

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Factors influencing drug targeting involve the type of targeting, targeting moieties, targeting sites, drug carriers, and ligands

Conclusion: Here, we identify TSC22D4 as a novel Akt interacting protein