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Specifically, TMPRSS2 processes the SARS-CoV-2 S-protein and enables the viral entry into host cells within 100-fold during infections and clinical conditions such as sepsis, renal ischemia-reperfusion injury and acute lung injury (ALI) 464

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Pregnancy planning & breastfeeding Generally not recommended during pregnancy, and breastfeeding requires clinician guidance based on labelling and individual risk/benefit