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The results painted a complex picture of GLP-1RAs impact

To achieve lasting results, weight loss medications are most effective when combined with a healthy diet, regular physical activity, and lifestyle interventions

(2024) found that GLP-1 receptor agonists significantly reduced diabetic foot ulcer risk compared to insulin (HR: 0.44, 95% CI: 0.320.60) for short-term use and (HR: 0.74, 95% CI: 0.600.92) for long-term use

Those receiving the drug lost about 25 pounds on average, vs

[7] [8] For weight management, NICE restricts their use to specialist weight management services with specific BMI thresholds and stopping rules