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Initially named as philothion, many works have tried to establish and elucidate its pivotal role in aerobic life.[] Glutathione exists in a reduced form (GSH) and an oxidized form (GSSG)

While TRP itself did not show a notable change, its indole-containing metabolite I3AA was significantly elevated, as was the ratio of I3AA/TRP, possibly indicating a shift away from the serotonergic pathway of TRP metabolism

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