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The mammalian enzymes occur in seven classes 9 of which members of the pi, mu, and alpha classes are major contributors to biotransformation of xenobiotics 10

MMPs are important proteolytic enzymes necessary for the maintenance of the integrity of the extracellular matrix

In Phase I, enzymes use oxygen to modify toxic compounds, often making them temporarily more reactive

Therefore, it is tempting to speculate that the effects of these compounds are, in part, an expression of their ability to quench the toxic effect of ROS