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J Med Invest (2018) 65(1.2):917

This finding is consistent with a previous study in which mice lacking TRPM5 function exhibited a decline in glucose tolerance and an impaired GSIS [31, 32]

Clinical trials test 0.16 to 4.5 mg subcutaneously once weekly (Lau 2021, Lancet)

272 Hippo/YAP signaling pathway The Hippo signaling pathway, a highly conserved signaling pathway in mammals, contributes to regulating cell proliferation, survival, and differentiation to control the organ size, tissue regeneration and tumorigenesis

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