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Knockout of HGMB1 promoted the expression of NRF2 and its downstream targets, including HO-1, NQO1, GCLC, and GCLM, prevented the production of ROS and LDH and upregulated the level of GPX4 in renal mesangial cells (Fig

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Because NE and NETs are identified as therapeutic targets in cancer, pharmacological DPP1 inhibition can also be envisaged as a therapeutic strategy to prevent primary tumor growth and secondary organ metastasis (162) and strongly reduced intracellular NSP activities and proteins (163)