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The role of SGLT-2 inhibitors, including empagliflozin, dapagliflozin, and ipragliflozin, in protecting against MASLD progression involves decreasing de novo lipogenesis, fatty acid uptake, and hepatic triglyceride secretion while promoting vital regulatory genes of fatty acid -oxidation (152)

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Human NAT1 and human NAT2 have distinct but overlapping substrate profiles and also have specific substrates which can be used as probe substrates for each particular isoenzyme