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In cell experiments, GLP-1 was found to have more mechanisms that may inhibit liver fat synthesis, such as FAM3A, NRF2, NaB, SHP1/AMPK, NLRP3, FGF21, IRS2, and other signaling pathways, which also provided direct evidence for the role of GLP-1R in the regulation of lipid metabolism in the liver

doi: 10.1016/S01670115(96)001127 161 StruthersRSGaddyKurtenDValeWW

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Briefly, 3 10 4 cells (SKM-1 and U-937) or peripheral blood mononuclear cells (PBMC) were cultured in 96 well plates with a serum-free RPMI-1640 medium and treated with various concentrations of thiotert (040 M) for 12 h

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