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For instance, leptin suppresses the activity of AMP-activated protein kinase (AMPK) in POMC neurons, which is permissive for their firing and subsequent peptide production [7]

Others prefer intermittent approaches: taking medication for 6-12 months, stopping to assess their natural baseline, and restarting if weight regain occurs

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Many of these benefits relate to weight loss, but studies are underway to understand how these medications might affect health through additional mechanisms