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The melanocytes are cells that do not derive from the ectoderm, but from the neural crest, and that in their migration are then disposed in correspondence with the basal keratinocytes (of the dermo-epidermal junction), typically with a well established relationship, in general we have 1 melanocyte every 10 basic keratinocytes more or less

all 4 histamine receptors H1R-H4R are found in the digestive tract and they have excitatory actions there (ref)

Hallgren, S., Sinjari, T., Hkansson, H

GLP-1 agonists are an effective medication in treating type 2 diabetes mellitus

There was a significant increase from baseline in insulin levels at 60, 90 and 120 minutes in high GLP-1 T2D group ( Figure 3D ), resulting in significantly greater LS-mean increment from baseline in these insulin levels in high GLP-1 compared with low GLP-1 groups ( Figure 3E )