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The 5:2 method restricts calorie consumption to 500600 cal on two non-consecutive days, permitting a regular diet on the remaining days (6)

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This targeted strategy can lead to faster, more significant improvements in cholesterol and cardiovascular markers

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52 GLP-1R agonists also regulate gene expression related to cell maturation (pancreatic and duodenal homeobox 1, MAF bZIP transcription factor A, and neuronal differentiation 1, upregulated) and to apoptosis (thioredoxin interacting protein, CASP3, and B-cell lymphoma 2 (Bcl-2) associated X, apoptosis regulator, downregulated)