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Although many hormones increase the glucose level in blood and exert mutual compensatory effects, insulin is the only blood glucose-lowering hormone that is indispensable for maintaining regular blood glucose levels, indicating an essential role of pancreatic islet homeostasis in blood glucose control

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This structural work provided an atomic-resolution frame for interpreting the pharmacological asymmetry reported in the earlier characterization studies, and it is the principal structural reference cited by subsequent reviews

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