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High end GPCR design: crafted ligand design and druggability analysis using protein structure, lipophilic hotspots and explicit water networks

Lp(a) levels less than 10 mg/dL (18 nmol/L) had the lowest risk.[ref] 28% increased relative risk of major cardiac event with Lp(a) 10 to 49 mg/dL (18 105 nmol/L) 44% increased relative risk of major cardiac event with Lp(a) between 50 to 99 mg/dL (105213 nmol/L) 114% increased relative risk (a bit more than double the risk) of major cardiac event with Lp(a) 100 mg/dL (214 nmol/L) In women specifically: A 2026 study involving almost 30,000 women showed that the risk of major cardiac events increased almost linearly starting at Lp(a) levels over 30 mg/dL

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Vernero M, De Blasio F, Ribaldone DG, Bugianesi E, Pellicano R, Saracco GM, et al

Lancet 360:1115 (2002)