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The miR-522 inside exosomes, generated from cancer-associated fibroblasts (CAFs), can block lipid-ROS accumulation by targeting ALOX15 and thus inhibit ferroptosis (Zhang H
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Tregs, in particular, are crucial in mitigating inflammatory responses and preventing autoimmune diseases by suppressing other cell types (88)
Obesity is a multifactorial disorder influenced by genetic or environmental factors, and the incidence has tripled since 1975 as reported by the WHO (131)
In another COR study where all participants made intensive lifestyle modifications, weight loss averaged 9.3% with Contrave vs 5.1% with placebo at 56 weeks
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