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Such an animal model was constructed by injecting complete Freunds adjuvant directly at the right hind ankle joint of mice, then the immunization was let to continue for 15 days, which would lead to a distinct arthroncus of joint (Supplementary Fig

Acknowledgements We acknowledge support from National Institute on Alcohol Abuse and Alcoholism (AA029831), National Institute on Aging (AG057557, AG061388, AG062272, AG07664), from National Cancer Institute Case Comprehensive Cancer Center (CA221718, CA043703, CA2332216)

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