Conventional treatments range from rest and ice to custom orthotics, physical therapy, night splints, extracorporeal shock wave therapy, and corticosteroid injections
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One clinical study found that a GHK-Cu cream was more effective at reducing wrinkles and increasing skin density than both a placebo and vitamin K cream
Across those trials the compound's tolerability was reported as comparable to placebo, with no statistically significant effects detected on serum IGF-1, fasting glucose, insulin, HbA1c, cortisol, or thyroid hormones at the levels studied, and no serious adverse events attributed to the compound [7]
[2] The gut microbiome connection is worth noting in this context