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As an example, findings from a phase I clinical study on nabulizumab, an anti-PD-1 antibody for solid tumor treatment, indicated survival rates of 22.4 and 16.8 months for non-small cell lung cancer and renal cell carcinoma, respectively [115]

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further provided evidence that this neural circuitry in mice is involved in the development of novel preference: when a stimulus was paired with chemo-genetic activation of cNTS proenkephaline-neurons, it became the preferred stimulus, thus less sweet solutions were preferred over sweeter ones, while silencing their synaptic activity prevented the development of preference (Tan et al., 2020)

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Neurological symptoms in the lower extremities are also a symptom of spinal stenosis itself