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The body absorbs B12 through a complex mechanism involving intrinsic factor, a protein produced in the stomach

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B12 injections and IV infusions have been around for a while

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Malabsorption (insufficient absorption of vitamin B12in the intestine) through, Insufficient production of intrinsic factor (a protein that is formed in the gastric mucosa and isrequiredfor the absorption of vitamin B12), Diseases in the terminal segment of the ileum (part of the small intestine), e.g