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Genetics plays a role here, and people who have genetically lower IgE levels are less likely to have chronic urticaria.[ref] Mast cells, atrial fibrillation, and cardiac diseases: Researchers estimate that there are ~50,000 mast cells/g of human heart tissue

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doi: 10.1017/S0967199409990293 84 JahromiBNSadeghiSAlipourSParsanezhadMEAlamdarlooSM