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As high-energy-demand cells, cerebral neurons require continuous bioenergetic supply to power neurotransmitter biosynthesis and vesicular secretion, action potential propagation, and synaptic plasticity modulation

Alternatively, switching to non-oral progesterone delivery (Mirena IUD or transvaginal progesterone) eliminates the concern entirely

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This process prevents the formation of lipid peroxides and subsequent ferroptosis by separating PUFAs from cellular membranes

doi: 10.1113/expphysiol.2006.034876