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However, because the brain uses the same dopamine pathways for other rewards (like shopping, alcohol, or even social interaction), some researchers believe the drug may act as a general reward dampener

MASH develops when fat accumulates in the liver

It activates three hormone receptors involved in metabolic regulation : GLP-1 (glucagon-like peptide-1): reduces appetite and slows gastric emptying GIP (glucose-dependent insulinotropic polypeptide): supports insulin response and metabolic efficiency Glucagon: increases energy expenditure and promotes fat utilization Because of this three-pathway action, retatrutide is often described as a triple-agonist medication

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