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Two large 72-week clinical trials that evaluated terzepatide in individuals who were overweight or obese found that by the end of the study, people who also dieted and exercised reported statistically significant weight loss compared to those who took the placebo

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Phentermine increases norepinephrine in the brain, while GLP-1 agonists like semaglutide bind to GLP-1 receptors throughout the body to regulate hormones and metabolism

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Both drugs appear to dampen the mesolimbic dopaminergic reward pathway, which is why many patients describe reduced cravings for alcohol, sweets, and ultra-processed food within the first month