Formulation considerations affect topical efficacy significantly
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Aminosalicylates The 5-aminosalicylic acid (5-ASA) class of drugs (mesalazine and sulphasalazine) are considered safe and effective long-term treatment options for IBD, and are available in both oral and rectal preparations (suppositories, enemas and foams)[1,4]
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Thus, our observations that tax6 mutants show longlasting calcium fluxes that fail to resume basal prestimulus levels may explain the hyperadaptation phenotypes scored via behavioral outputs (Kuhara et al , 2002)