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Pediatr Nephrol 31:13131320 Mitsnefes MM, Kimball TR, Kartal J, Witt SA, Glascock BJ, Khoury PR, Daniels SR (2006) Progression of left ventricular hypertrophy in children with early chronic kidney disease: 2-year follow-up study

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Researchers concluded that these populations were more active metabolically (therefore having relative carnitine deficiency)

However, currently available agents are still limited (Table 1) and despite their considerable merits, multiple concerns were raised concerning the use of these inhibitors, specifically those targeting RIPK1

In obesity and metabolic dysfunction, NNMT expression is often higher in adipose tissue, and research has linked NNMT activity to changes in energy expenditure and fat storage behavior in adipocytes