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They treated 8 pouchees with the GLP-1 drug Liraglutide (trade name Saxenda ) in a well-designed, placebo-controlled, double-blind, cross-over clinical trial and showed a 35% reduction in toilet frequency on treatment compared to placebo, a reduction in urgency and better stool consistency and the drug was safe and well tolerated
Medical supervision is essential because peptides influence hormonal and metabolic pathways that require monitoring
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The decrease in size of the GLA-KO human iPSC kidney organoids was attenuated in accordance with ERT (Fig
These results are consistent with results observed in mice (26) and strongly support a role for gut microbiota in BB generation from dietary l-carnitine in humans
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