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195,196 Future research should elucidate the roles of SIRT1 in the microbiotaimmunemetabolism cross-pathways and evaluate its potential therapeutic synergy with microbiota-targeted interventions, including probiotics and dietary fibers
Critically, these lipid peroxidation products, particularly 4-HNE and 4-oxo-2-nonenal (ONE), enhance the stability and yield of -syn oligomers, promoting their pathological deposition
This makes it more accessible for those seeking effective weight management solutions
Contribution statement JIM contributed to the design of the study, constructed the model, performed the analysis and literature search, acquisition and interpretation of the data, and wrote and revised the manuscript