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Wegovy (semaglutide): In the STEP UP trial, adults treated with the highest tested dose of Wegovy (7.2 mg) achieved an average weight loss of 20.7% of their body weight over 72 weeks

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The rapid onset without psychomimetic effects places it in a different category from ketamine, another fast-acting antidepressant approach that carries significant abuse potential

Studies show slu pp can activate similar molecular cascades to those seen during endurance exercise, so scientists can study cellular adaptations without actual physical stress protocols