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But if any of the following apply to you, your glutathione needs are likely elevated: Chronic digestive issues (IBS, IBD, SIBO, Candida overgrowth) Chronic fatigue or poor sleep Mood symptoms: anxiety, depression, brain fog Chronic infections or a history of immune dysfunction Significant toxin or alcohol exposure Heavy training or high athletic output Metabolic issues (obesity, blood sugar dysregulation) Neurological symptoms (tinnitus, cognitive decline) Older age
Because the dose is small, the cost is too
DPP-4 Inhibitors Mechanism of action Competitive inhibition of dipeptidyl-peptidase 4 slows degradation of endogenous incretins (GLP-1, GIP) Glucose-dependent insulin secretion Post-prandial glucagon release No direct effect on weight or insulin sensitivity Glycaemic efficacy Advantages Weight-neutral useful when metformin + SU cause weight concern Low hypoglycaemia risk (incretin-dependent action) Oral, generally once-daily
