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SHR rats originated at the Kyoto School of Medicine in 1963, where Okamoto mated an outbred Wistar Kyoto male with marked elevation of blood pressure to a female with slightly elevated blood pressure [24]

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These include: Permeability across the intestinal wall Chemical and metabolic stability (how easily they break down) Gastrointestinal (GI) transit time Molecular size, which is often the biggest barrier To overcome these challenges, scientists have developed different strategies for improving oral delivery: Absorption enhancers These substances temporarily make the intestinal barrier more permeable or act as carriers to help peptides cross it

Senyawa ini membantu menetralkan radikal bebas berbahaya dalam tubuh, mengurangi stres oksidatif, dan menurunkan risiko penyakit kronis seperti penyakit jantung, diabetes, dan kanker