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As for cosmetics, the CIR (Cosmetic Ingredient Review) concluded that the amount of BHT used in cosmetic products is low (usually around 0.01-0.1%), it does not penetrate skin far enough to be absorbed into the bloodstream and it is safe to use in cosmetics

Future research should focus on the development of additional activators of the SLC7A11/GPX4 pathway with pharmaceutical properties and conduct clinical trials where appropriate

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Ann N Y Acad Sci 1398(1):519 Lu J, Jiang H, Liu B, Baiyun R, Li S, Lv Y, Li D, Qiao S, Tan X, Zhang Z (2018) Grape seed procyanidin extract protects against Pb-induced lung toxicity by activating the AMPK/Nrf2/p62 signaling axis