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[9] The relationship between GLP-1 medications and reflux is likely multifactorial, involving direct pharmacological effects on gastric motility and individual patient susceptibility factors including body weight, hiatal hernia presence, and baseline LES function
Before starting dual therapy, discuss with your provider baseline metabolic labs, medication interactions, tolerance to GLP-1 side effects, and whether genetic or biomarker insights might inform your treatment plan
This is the same directional change sought with FDA-approved therapies like minoxidil, but achieved through a distinct upstream mechanism
However dulaglutide doses greater than 0.5 mg/kg were demonstrated to increase hyperplasia of thyroid C cells ( These data suggest that rodents are particularly sensitive to the effects of GLP-1 agonists on thyroid C cells but these foindings could not be considered as predictive of an increased risk of thyroid C-cell tumors in patients under GLP-1 receptor agonist therapy ( Insulin Insulin is a widely prescribed glucose-lowering agent (Sims et al., 2021) especially in patients affected by type 1 diabetes mellitus (T1DM) as well as in some patients with Type 2 diabetes mellitus