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Notably, B2M-CuS NPs are safe for normal chondrocytes because they are targeted specifically to senescent chondrocytes, which have greater ROS sensitivity than normal cells [53, 54]

Since decreased Parasutterella relative abundance may accompany increased stress 80,81 , the increased Parasutterella relative abundance that occurred in this study following diet switch likely arose from the weight loss-mediated negative energy state

IGF-1 LR3 bypasses this because it doesnt bind IGFBP-3 or other binding proteins effectively

Eur J Pharmacol 2016

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