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The SURPASS-2 trial (Frias et al., NEJM , 2021) directly compared tirzepatide to semaglutide 1 mg in patients with type 2 diabetes and found tirzepatide superior across all dose levels for both weight loss and glycemic control
The molecule that emerged from this foundational work carried a disabling flaw as a therapeutic scaffold: native GLP-1 is degraded almost immediately by the serine protease dipeptidyl peptidase-4 (DPP-4), which cleaves the peptide between residues 8 and 9 and confers a circulating half-life of under two minutes [4]
For those researching their options, SeekPeptides provides detailed guides on verified semaglutide providers including Empower Pharmacy , Olympia Pharmacy , and BPI Labs to help you make informed decisions about sourcing
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