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The Verdict: For weight loss and metabolic correction, GLP-1 agonists are the clinically validated choice

It is therefore relatively simple to produce synthetically and characterize analytically

It may be reasonable to focus on whether the combination of GLP-1RAs and SGLT2is, which are expected to have complementary effects based on large-scale clinical trial results, can further reduce cardiovascular and renal events in patients with diabetes

* Correspondence: Renshi Xu, [email protected] These authors have contributed equally to this work ORCID: Wenzhi Chen, orcid.org/0000-0003-0720-5888

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