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A cross-sectional survey that enrolled healthy men (n=1514) and women (1528) who reported intakes of choline and betaine calculated from food-frequency questionnaire and food-composition tables found that participants who consumed more than 310 mg/d had lower plasma C-reactive protein (CRP), IL-6 and TNF- than participants reporting choline intake below 250 mg/d (142)

At the same time, bile acid signaling pathways, including the farnesoid X receptor (FXR)FGF15 and TGR5glucagon-like peptide-1(GLP-1) axes, are disrupted, further promoting hepatic lipid accumulation and immune dysregulation