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Some people might also notice mild diarrhea or a feeling of swelling in their body, but these are typically temporary

Be aware of the risks of B-12 as explained in our B Vitamin Supplements Review, which includes our Top Picks for vitamin B-12 and other B vitamins

The STEP 1 trial, published in the New England Journal of Medicine , demonstrated that participants receiving semaglutide 2.4 mg weekly lost an average of 14.9 percent of their body weight over 68 weeks, compared to 2.4 percent with placebo (Wilding et al., 2021)

The timeframe for improvement varies considerably between individuals

Rare but Serious Reactions: Seek immediate medical attention for signs of a severe allergic reaction (anaphylaxis), such as hives, difficulty breathing, or swelling of the face and throat